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Create duplicates in concentration data with Pre-dose and Last Values for Dosing Cycles

Source: R/dose_profile_duplicates.R
dose_profile_duplicates.Rd

This function duplicates and adjusts concentration data to ensure all dosing cycles have complete pre-dose and last concentration values. It is designed for use in pharmacokinetic analyses where dosing intervals and concentration values need to be aligned for each dose.

Usage

dose_profile_duplicates(
  conc_data,
  groups = c("USUBJID", "DOSNO", "ANALYTE"),
  dosno = "DOSNO",
  arrlt = "ARRLT",
  afrlt = "AFRLT",
  nrrlt = "NRRLT",
  nfrlt = "NFRLT"
)

Arguments

conc_data

A data frame containing concentration data.

groups

A character vector of column names to use for grouping (e.g., c("USUBJID", "ANALYTE", "DOSNO")).

dosno

Column name for the dose number (default: "DOSNO").

arrlt

Column name for time from the most recent dose.

afrlt

Column name for time from the first dose.

nrrlt

Column name for the numeric relative time.

nfrlt

Column name for the nominal relative time.

Value

A data frame with adjusted concentration data, including:

  • Duplicated pre-dose values assigned to the previous dose.

  • Duplicated last values assigned to the next dose if pre-dose values are missing, filtered so only samples within 24 hours of the next dose are included.

  • Sorted by the grouping variables and relative time.

Examples

# Example usage
conc_data <- data.frame(
USUBJID = c("001", "001", "001", "001", "001", "001", "001", "001", "001", "001"),
AVAL = c(1, 2, 3, 4, 5, 6, 7, 8, 9, 10),
DOSNO = c(1, 1, 1, 2, 2, 2, 2, 3, 3, 3),
ARRLT = c(-1, 0, 1, -1, 0, 1, 2, 0, 1, 2),
AFRLT = c(-1, 0, 1, 2, 3, 4, 5, 6, 7, 8),
NRRLT = c(-1, 0, 1, -1, 0, 1, 2, 0, 1, 2),
NFRLT = c(-1, 0, 1, 2, 3, 4, 5, 6, 7, 8)
)
result <- dose_profile_duplicates(conc_data,
                            groups = c("USUBJID", "DOSNO"), dosno = "DOSNO")