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Create PK Concentration Dataset

Source: R/format_data.R
format_pkncaconc_data.Rd

This function creates a pharmacokinetic concentration dataset from the provided ADNCA data.

Usage

format_pkncaconc_data(
  ADNCA,
  group_columns,
  time_column = "AFRLT",
  rrlt_column = "ARRLT",
  route_column = "ROUTE",
  nca_exclude_reason_columns = NULL
)

Arguments

ADNCA

A data frame containing the ADNCA data.

group_columns

A character vector specifying the columns to group by.

time_column

A character string specifying the time column.

rrlt_column

A character string specifying the time since last dose column.

route_column

A character string specifying the route column.

nca_exclude_reason_columns

A character vector specifying the columns to indicate reasons for excluding records from NCA analysis.

Value

A data frame containing the filtered and processed concentration data.

Details

The function performs the following steps:

  • Checks for required columns and data.

  • Filters out rows with EVID = 0 and PARAMCD containing "DOSE" (dosing data- not CDISC standard)

  • Creates DOSNOA variable, sequential numbers based on time of dose

  • Creates a 'std_route' column with PKNCA values "intravascular" or "extravascular" based on route_column (ROUTE, CDISC: C66729).

  • Arranges the data by group_columns.

Examples

adnca <- read.csv(system.file("shiny/data/example-ADNCA.csv", package = "aNCA"))
conc_data <- format_pkncaconc_data(ADNCA = adnca,
                                   group_columns = c("STUDYID", "DOSETRT", "USUBJID", "PARAM"),
                                   time_column = "AFRLT",
                                   rrlt_column = "ARRLT",
                                   route_column = "ROUTE")