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Create PK Concentration Dataset

Source: R/format_data.R
format_pkncaconc_data.Rd

This function creates a pharmacokinetic concentration dataset from the provided ADNCA data.

Usage

format_pkncaconc_data(
  ADNCA,
  group_columns,
  time_column = "AFRLT",
  rrlt_column = "ARRLT",
  route_column = "ROUTE"
)

Arguments

ADNCA

A data frame containing the ADNCA data.

group_columns

A character vector specifying the columns to group by.

time_column

A character string specifying the time column.

rrlt_column

A character string specifying the time since last dose column.

route_column

A character string specifying the route column.

Value

A data frame containing the filtered and processed concentration data.

Details

The function performs the following steps:

  • Checks for required columns and data.

  • Filters out rows with EVID = 0 and PARAMCD containing "DOSE" (dosing data- not CDISC standard)

  • Calculates TIME_DOSEas the time of dose reference by the PK sample

  • Creates DOSNOA variable, sequential numbers based on time of dose

  • Adds a 'std_route' column taking values "intravascular" or "extravascular".

  • Arranges the data by group_columns.

Examples

if (FALSE) { # \dontrun{
  # Example usage:
  conc_data <- format_pkncaconc_data(ADNCA,
                                     group_columns,
                                     "AFRLT",
                                     "ROUTE")
} # }