Skip to contents

Create Dose Intervals Dataset

Source: R/intervals.R
format_pkncadata_intervals.Rd

This function creates a dataset with dose intervals and specified pharmacokinetic parameters.

Usage

format_pkncadata_intervals(pknca_conc, pknca_dose, start_from_last_dose = TRUE)

Arguments

pknca_conc

A PKNCAdose object containing the concentration data.

pknca_dose

A PKNCAdose object containing the dose data.

start_from_last_dose

Logical defining if start is at time of last dose or C1.

Value

A data frame containing the dose intervals and specified pharmacokinetic parameters.

Details

The function performs the following steps:

  • Creates a vector with all pharmacokinetic parameters.

  • Based on dose times, creates a data frame with start and end times.

  • If TRTRINT column is present in data, sets last dose end time to start + TRTRINT, or if TRTRINT is NA then either Inf if only one dose present, or max end time if not.

  • If no TRTRINT column in data, sets last dose end time to the time of last sample or Inf if single dose data.

  • Adds logical columns for each specified parameter.

Assumes that multiple dose data will have a TRTRINT column or contain multiple doses in dataset

Examples

adnca <- read.csv(system.file("shiny/data/example-ADNCA.csv", package = "aNCA"))
pknca_data <- PKNCA_create_data_object(adnca)
pknca_conc <- pknca_data$conc
pknca_dose <- pknca_data$dose
dose_intervals <- format_pkncadata_intervals(pknca_conc, pknca_dose)