Create Dose Intervals Dataset — format_pkncadata

This function creates a dataset with dose intervals and specified pharmacokinetic parameters.

Usage

format_pkncadata_intervals(
  pknca_conc,
  pknca_dose,
  params = c("aucinf.obs", "aucint.last", "auclast", "cmax", "half.life", "tmax",
    "lambda.z", "lambda.z.n.points", "r.squared", "adj.r.squared", "lambda.z.time.first",
    "aucpext.obs", "aucpext.pred", "clast.obs", "cl.obs"),
  start_from_last_dose = TRUE
)

Arguments

pknca_conc: A PKNCAdose object containing the concentration data.
pknca_dose: A PKNCAdose object containing the dose data.
params: A character vector specifying the pharmacokinetic parameters to include.
start_from_last_dose: Logical defining if start is at time of last dose or C1.

Value

A data frame containing the dose intervals and specified pharmacokinetic parameters.

Details

The function performs the following steps:

Creates a vector with all pharmacokinetic parameters.
Based on dose times, creates a data frame with start and end times.
If TRTRINT column is present in data, sets last dose end time to start + TRTRINT, or if TRTRINT is NA then either Inf if only one dose present, or max end time if not.
If no TRTRINT column in data, sets last dose end time to the time of last sample or Inf if single dose data.
Adds logical columns for each specified parameter.

Assumes that multiple dose data will have a TRTRINT column or contain multiple doses in dataset

Examples

adnca <- read.csv(system.file("shiny/data/example-ADNCA.csv", package = "aNCA"))
pknca_data <- PKNCA_create_data_object(adnca)
pknca_conc <- pknca_data$conc
pknca_dose <- pknca_data$dose
params <- c("aucinf.obs", "cmax", "half.life", "tmax", "lambda.z")
dose_intervals <- format_pkncadata_intervals(pknca_conc, pknca_dose, params)