Create Dose Intervals Dataset — format_pkncadata_intervals • aNCA

This function creates a dataset with dose intervals and specified pharmacokinetic parameters.

Usage

format_pkncadata_intervals(
  pknca_conc,
  pknca_dose,
  params = c("aucinf.obs", "aucint.last", "auclast", "cmax", "half.life", "tmax",
    "lambda.z", "lambda.z.n.points", "r.squared", "adj.r.squared", "lambda.z.time.first",
    "aucpext.obs", "aucpext.pred", "clast.obs", "cl.obs"),
  start_from_last_dose = TRUE
)

Arguments

pknca_conc: A PKNCAdose object containing the concentration data.
pknca_dose: A PKNCAdose object containing the dose data.
params: A character vector specifying the pharmacokinetic parameters to include.
start_from_last_dose: Logical defining if start is at time of last dose or C1.

Value

A data frame containing the dose intervals and specified pharmacokinetic parameters.

Details

The function performs the following steps:

Creates a vector with all pharmacokinetic parameters.
Based on dose times, creates a data frame with start and end times.
If TAU column is present in data, sets last dose end time to start + TAU
If no TAU column in data, sets last dose end time to the time of last sample
Adds logical columns for each specified parameter.

Examples

if (FALSE) { # \dontrun{
  # Example usage:
  dose_intervals <- format_pkncadata_intervals(pknca_conc, pknca_dose, params)
} # }