Calculate Matrix Ratios This function calculates the ratios for a given data set, based on the shared time points for each matrix concentration sample. The user can input multiple tissues for which ratios should be calculated.
Source:R/ratio_calculations.R
multiple_matrix_ratios.RdThe ratios are calculated as specimen1 / specimen 2.
Usage
multiple_matrix_ratios(
data,
matrix_col,
conc_col,
units_col,
groups = c("NFRLT", "USUBJID"),
spec1,
spec2
)Arguments
- data
A data frame containing the concentration data.
- matrix_col
A character string specifying the column name for the matrix type.
- conc_col
A character string specifying the column name for the concentration data.
- units_col
A character string specifying the column name for the units.
- groups
A character vector of grouping variables to use for the analysis. Must include time column, USUBJID, and optionally, other grouping variables.
- spec1
A character string specifying the value for the first specimen type(s) in the matrix_col.
- spec2
A character string specifying the value for the second specimen type(s) in the matrix_col.
Examples
data <- data.frame(
USUBJID = c("A", "A", "A", "A", "A", "A", "A", "A", "A", "A", "A", "A"),
NFRLT = c(0, 1, 2, 0, 1, 2, 0, 1, 2, 0, 1, 2),
MATRIX = c("BLOOD", "BLOOD", "BLOOD", "PLASMA", "PLASMA", "PLASMA",
"BRAIN", "BRAIN", "BRAIN", "LIVER", "LIVER", "LIVER"),
CONC = c(10, 20, 15, 25, 30, 40, 5, 10, 8, 12, 18, 16),
UNITS = rep("ng/mL", 12)
)
multiple_matrix_ratios(data, "MATRIX", "CONC", "UNITS", c("NFRLT", "USUBJID"), "BLOOD", "PLASMA")
#> # A tibble: 3 × 8
#> # Rowwise:
#> NFRLT USUBJID Ratio_Type Spec1_Value Spec1_Units Spec2_Value Spec2_Units Ratio
#> <dbl> <chr> <chr> <dbl> <chr> <dbl> <chr> <dbl>
#> 1 0 A BLOOD/PLA… 10 ng/mL 25 ng/mL 0.4
#> 2 1 A BLOOD/PLA… 20 ng/mL 30 ng/mL 0.667
#> 3 2 A BLOOD/PLA… 15 ng/mL 40 ng/mL 0.375