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Reshape PKNCA Results

Source: R/pivot_wider_pknca_results.R
pivot_wider_pknca_results.Rd

This function reshapes the structure of the results produced by the main function of the PKNCA package (pk.nca) in a way that each row represents all the main results summarized for each profile in each individual/subject. Excluding the ID variables, each column name corresponds with a calculated parameter and between brackets its corresponding units. AUC intervals, if present, are be added as additional columns.

Usage

pivot_wider_pknca_results(myres)

Arguments

myres

The output of PKNCA::pk.nca. It makes some additional assumptions:

  1. CDISC denomination of actual and nominal time variables (AFRLT, ARRLT, NFRLT, NRRLT).

  2. Intervals must include a column (type_interval) to differentiate between the custom AUC ranges ("manual") and main parameter calculations ("main").

  3. Includes PPSTRES and PPSTRESU variables in results dataset.

  4. Columns start_dose and end_dose must express the actual start and end times of the dose, relative to the last reference dose.

  5. Temporarily: CDISC denomination of PK parameters related to half-life: "LAMZNPT", "LAMZLL", "LAMZ" Used to derive LAMZNPT and LAMZMTD.

Value

A data frame which provides an easy overview on the results from the NCA in each profile/subject and how it was computed lambda (half life) and the results of the NCA parameters (cmax, AUC, AUClast)