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Calculate bioavailability for intravascular vs extravascular aucs

Source: R/bioavailability.R
pknca_calculate_f.Rd

This function calculates bioavailability (F) based on AUC (Area Under Curve) data extracted from res_nca. It computes individual bioavailability where IV and EX data are available for a subject. If IV data is missing, it estimates bioavailability using the mean IV values for that grouping.

Usage

pknca_calculate_f(res_nca, f_aucs)

Arguments

res_nca

A list containing non-compartmental analysis (NCA) results, including concentration and dose data.

f_aucs

A character vector of the comparing AUC parameter/s including the prefix f_ (e.g., c("f_aucinf.obs", "f_auclast")).

Value

A data frame with calculated absolute bioavailability values (FABS_) for individual subjects where IV data is available. If IV data is missing, it estimates bioavailability using the mean IV AUC for that grouping.

Details

  • The function extracts AUC data from res_nca$data$conc$data and filters for selected AUC types.

  • It separates data into intravascular (IV) and extravascular (EX) groups.

  • Individual bioavailability is calculated for subjects with both IV and EX data using PKNCA function pk.calc.f.

  • If IV data is missing for a subject, the function estimates bioavailability using mean IV values for that grouping.

  • The final output includes bioavailability estimates for individual subjects and mean-based estimates.