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Conditionally Verify and Override PK Parameters Based on Sample Type

Source: R/format_data.R
verify_parameters.Rd

This helper function updates a PKNCA intervals data frame by verifying and overriding specific pharmacokinetic parameters depending on whether the sample is identified as excreta (e.g., urine, feces, bile). Parameters related to excretion (such as ae, fe, and those starting with "clr.") are selectively enabled only for excreta samples and set to FALSE otherwise.

Usage

verify_parameters(pknca_intervals, params, all_pknca_params)

Arguments

pknca_intervals

A data frame containing PKNCA interval information, including pharmacokinetic parameters and a PCSPEC column that describes the specimen type.

params

A character vector of parameter names selected by the user. Only these parameters will remain TRUE for excreta types.

all_pknca_params

A character vector of all pharmacokinetic parameters that may be present in pknca_intervals. These will be checked and updated accordingly.

Value

A modified version of the pknca_intervals data frame with appropriate parameters updated based on the specimen type.