Metadata Holding Grading Criteria for NCI-CTCAEv4
Details
This metadata has its origin in the ADLB Grading Spec Excel file which ships with {admiral}
and can be accessed using system.file("adlb_grading/adlb_grading_spec.xlsx", package = "admiral")
in sheet = "NCICTCAEv4".
The dataset contained in there has the following columns:
SOC: variable to hold the SOC of the lab test criteria.TERM: variable to hold the term describing the criteria applied to a particular lab test, eg. 'Anemia' or 'INR Increased'. Note: the variable is case insensitive.Grade 1: Criteria defining lab value as Grade 1.Grade 2: Criteria defining lab value as Grade 2.Grade 3: Criteria defining lab value as Grade 3.Grade 4: Criteria defining lab value as Grade 4.Grade 5: Criteria defining lab value as Grade 5.Definition: Holds the definition of the lab test abnormality.GRADE_CRITERIA_CODE: variable to hold code that creates grade based on defined criteria.SI_UNIT_CHECK: variable to hold unit of particular lab test. Used to check against input data if criteria is based on absolute values.VAR_CHECK: List of variables required to implement lab grade criteria. Use to check against input data.DIRECTION: variable to hold the direction of the abnormality of a particular lab test value. 'L' is for LOW values, 'H' is for HIGH values. Note: the variable is case insensitive.COMMENT: Holds any information regarding rationale behind implementation of grading criteria.
Note: Variables SOC, TERM, Grade 1, Grade 2,Grade 3,Grade 4,Grade 5, Definition
are from the source document on NCI-CTC website defining the grading criteria.
Common Terminology Criteria for Adverse Events (CTCAE)v4.0
From these variables only 'TERM' is used in the {admiral} code, the rest are for information and
traceability only.
See also
Other metadata:
atoxgr_criteria_ctcv5,
atoxgr_criteria_daids,
country_code_lookup,
dose_freq_lookup