Metadata Holding Grading Criteria for NCI-CTCAEv4Source:
Metadata Holding Grading Criteria for NCI-CTCAEv4
This metadata has its origin in the ADLB Grading Spec Excel file which ships with
and can be accessed using
system.file("adlb_grading/adlb_grading_spec.xlsx", package = "admiral")
in sheet = "NCICTCAEv4".
The dataset contained in there has the following columns:
SOC: variable to hold the SOC of the lab test criteria.
TERM: variable to hold the term describing the criteria applied to a particular lab test, eg. 'Anemia' or 'INR Increased'. Note: the variable is case insensitive.
Grade 1: Criteria defining lab value as Grade 1.
Grade 2: Criteria defining lab value as Grade 2.
Grade 3: Criteria defining lab value as Grade 3.
Grade 4: Criteria defining lab value as Grade 4.
Grade 5: Criteria defining lab value as Grade 5.
Definition: Holds the definition of the lab test abnormality.
GRADE_CRITERIA_CODE: variable to hold code that creates grade based on defined criteria.
SI_UNIT_CHECK: variable to hold unit of particular lab test. Used to check against input data if criteria is based on absolute values.
VAR_CHECK: List of variables required to implement lab grade criteria. Use to check against input data.
DIRECTION: variable to hold the direction of the abnormality of a particular lab test value. 'L' is for LOW values, 'H' is for HIGH values. Note: the variable is case insensitive.
COMMENT: Holds any information regarding rationale behind implementation of grading criteria.
are from the source document on NCI-CTC website defining the grading criteria.
Common Terminology Criteria for Adverse Events (CTCAE)v4.0
From these variables only 'TERM' is used in the admiral code, the rest are for information and