Derive Reference Range Indicator

Derive Reference Range Indicator

Usage

derive_var_anrind(
  dataset,
  signif_dig = get_admiral_option("signif_digits"),
  use_a1hia1lo = FALSE
)

Arguments

dataset

Input dataset ANRLO, ANRHI, and AVAL are expected and if use_a1hia1lo is set to TRUE, A1LO and A1H1 are expected as well.

signif_dig

Number of significant digits to use when comparing values.

Significant digits used to avoid floating point discrepancies when comparing numeric values. See blog: How admiral handles floating points

use_a1hia1lo

A logical value indicating whether to use A1H1 and A1LO in the derivation of ANRIND.

Value

The input dataset with additional column ANRIND

Details

In the case that A1H1 and A1LO are to be used, ANRIND is set to:

• "NORMAL" if AVAL is greater or equal ANRLO and less than or equal ANRHI; or if AVAL is greater than or equal ANRLO and ANRHI is missing; or if AVAL is less than or equal ANRHI and ANRLO is missing

• "LOW" if AVAL is less than ANRLO and either A1LO is missing or AVAL is greater than or equal A1LO

• "HIGH" if AVAL is greater than ANRHI and either A1HI is missing or AVAL is less than or equal A1HI

• "LOW LOW" if AVAL is less than A1LO

• "HIGH HIGH" if AVAL is greater than A1HI

In the case that A1H1 and A1LO are not to be used, ANRIND is set to:

• "NORMAL" if AVAL is greater or equal ANRLO and less than or equal ANRHI; or if AVAL is greater than or equal ANRLO and ANRHI is missing; or if AVAL is less than or equal ANRHI and ANRLO is missing

• "LOW" if AVAL is less than ANRLO

• "HIGH" if AVAL is greater than ANRHI

See also

BDS-Findings Functions that returns variable appended to dataset: derive_basetype_records(), derive_var_analysis_ratio(), derive_var_atoxgr(), derive_var_atoxgr_dir(), derive_var_base(), derive_var_chg(), derive_var_ontrtfl(), derive_var_pchg(), derive_var_shift(), derive_vars_crit_flag()

Examples

library(tibble)
library(dplyr, warn.conflicts = FALSE)

vs <- tibble::tribble(
  ~USUBJID, ~PARAMCD, ~AVAL, ~ANRLO, ~ANRHI, ~A1LO, ~A1HI,
  "P01",       "PUL",    70,     60,    100,    40,   110,
  "P01",       "PUL",    57,     60,    100,    40,   110,
  "P01",       "PUL",    60,     60,    100,    40,   110,
  "P01",     "DIABP",   102,     60,     80,    40,    90,
  "P02",       "PUL",   109,     60,    100,    40,   110,
  "P02",       "PUL",   100,     60,    100,    40,   110,
  "P02",     "DIABP",    80,     60,     80,    40,    90,
  "P03",       "PUL",    39,     60,    100,    40,   110,
  "P03",       "PUL",    40,     60,    100,    40,   110
)

vs %>% derive_var_anrind(use_a1hia1lo = TRUE)
#> # A tibble: 9 × 8
#>   USUBJID PARAMCD  AVAL ANRLO ANRHI  A1LO  A1HI ANRIND   
#>   <chr>   <chr>   <dbl> <dbl> <dbl> <dbl> <dbl> <chr>    
#> 1 P01     PUL        70    60   100    40   110 NORMAL   
#> 2 P01     PUL        57    60   100    40   110 LOW      
#> 3 P01     PUL        60    60   100    40   110 NORMAL   
#> 4 P01     DIABP     102    60    80    40    90 HIGH HIGH
#> 5 P02     PUL       109    60   100    40   110 HIGH     
#> 6 P02     PUL       100    60   100    40   110 NORMAL   
#> 7 P02     DIABP      80    60    80    40    90 NORMAL   
#> 8 P03     PUL        39    60   100    40   110 LOW LOW  
#> 9 P03     PUL        40    60   100    40   110 LOW      
vs %>% derive_var_anrind(use_a1hia1lo = FALSE)
#> # A tibble: 9 × 8
#>   USUBJID PARAMCD  AVAL ANRLO ANRHI  A1LO  A1HI ANRIND
#>   <chr>   <chr>   <dbl> <dbl> <dbl> <dbl> <dbl> <chr> 
#> 1 P01     PUL        70    60   100    40   110 NORMAL
#> 2 P01     PUL        57    60   100    40   110 LOW   
#> 3 P01     PUL        60    60   100    40   110 NORMAL
#> 4 P01     DIABP     102    60    80    40    90 HIGH  
#> 5 P02     PUL       109    60   100    40   110 HIGH  
#> 6 P02     PUL       100    60   100    40   110 NORMAL
#> 7 P02     DIABP      80    60    80    40    90 NORMAL
#> 8 P03     PUL        39    60   100    40   110 LOW   
#> 9 P03     PUL        40    60   100    40   110 LOW