Calculates results for PKNCA analysis.

Usage

PKNCA_calculate_nca(pknca_data)

Arguments

pknca_data: Data object created using PKNCA::PKNCAdata() function.

Value

Results object with start and end times for each dose, from first dose and from most recent dose

Details

This function+ calculates results for PKNCA analysis using PKNCA::pk.nca(). It then joins the results with the dosing data, to create a full results data frame with the start and end times for each dose, from first and most recent dose.

Examples

example_data <- data.frame(
  STUDYID = rep("STUDY001", 6),
  PCSPEC = rep("Plasma", 6),
  ROUTE = rep("IV", 6),
  DRUG = rep("DrugA", 6),
  USUBJID = rep("SUBJ001", 6),
  DOSNO = rep(1, 6),
  ANALYTE = rep("AnalyteA", 6),
  AVAL = c(0, 5, 10, 7, 3, 1),
  AVALU = rep("ng/mL", 6),
  DOSEA = rep(100, 6),
  DOSEU = rep("mg", 6),
  AFRLT = c(0, 1, 2, 3, 4, 6),
  ARRLT = c(0, 1, 2, 3, 4, 6),
  NFRLT = c(0, 1, 2, 3, 4, 6),
  ADOSEDUR = rep(0.5, 6),
  RRLTU = rep("hour", 6)
)

# Create a PKNCAdata object
pknca_data <- PKNCA_create_data_object(example_data)

# Perform NCA calculations
nca_results <- PKNCA_calculate_nca(pknca_data)
#> Joining with `by = join_by(STUDYID, PCSPEC, DRUG, USUBJID)`