Creates a PKNCA::PKNCAdata object.
Details
This function creates a standard PKNCAdata object from ADNCA data. It requires the following columns in the ADNCA data:
STUDYID: Study identifier.
PCSPEC: Matrix.
ROUTE: Route of administration.
DRUG: Drug identifier.
USUBJID: Unique subject identifier.
DOSNO: Dose profile number.
ANALYTE: Analyte.
AVAL: Analysis value.
AVALU: AVAL unit.
DOSEA: Dose amount.
DOSEU: Dose unit.
AFRLT: Actual time from first dose.
ARRLT: Actual time from reference dose.
NFRLT: Nominal time from first dose.
ADOSEDUR: Duration of dose.
RRLTU: Time unit.
Creating pk concentration data using
format_pkncaconc_data().Creating dosing data using
format_pkncadose_data().Creating
PKNCAconcobject usingPKNCA::PKNCAconc(). with formulaAVAL ~ TIME | STUDYID + PCSPEC + DRUG + USUBJID / ANALYTE.Creating PKNCAdose object using
PKNCA::PKNCAdose(). with formulaDOSEA ~ TIME | STUDYID + PCSPEC + DRUG + USUBJID.Creating PKNCAdata object using
PKNCA::PKNCAdata().Updating units in PKNCAdata object so each analyte has its own unit.
Examples
adnca_data <- data.frame(
STUDYID = rep("STUDY001", 6),
PCSPEC = rep("Plasma", 6),
ROUTE = rep("IV", 6),
DRUG = rep("DrugA", 6),
USUBJID = rep("SUBJ001", 6),
DOSNO = rep(1, 6),
ANALYTE = rep("AnalyteA", 6),
AVAL = c(0, 5, 10, 7, 3, 1),
AVALU = rep("ng/mL", 6),
DOSEA = rep(100, 6),
DOSEU = rep("mg", 6),
AFRLT = c(0, 1, 2, 3, 4, 6),
ARRLT = c(0, 1, 2, 3, 4, 6),
NFRLT = c(0, 1, 2, 3, 4, 6),
ADOSEDUR = rep(0.5, 6),
RRLTU = rep("hour", 6)
)
PKNCA_create_data_object(adnca_data)
#> Formula for concentration:
#> AVAL ~ TIME | STUDYID + PCSPEC + DRUG + USUBJID/ANALYTE
#> <environment: 0x55cb82946478>
#> Data are dense PK.
#> With 1 subjects defined in the 'USUBJID' column.
#> Nominal time column is: NFRLT
#>
#> Data for concentration:
#> STUDYID PCSPEC ROUTE DRUG USUBJID DOSNO ANALYTE AVAL AVALU DOSEA DOSEU
#> STUDY001 Plasma IV DrugA SUBJ001 1 AnalyteA 0 ng/mL 100 mg
#> STUDY001 Plasma IV DrugA SUBJ001 1 AnalyteA 5 ng/mL 100 mg
#> STUDY001 Plasma IV DrugA SUBJ001 1 AnalyteA 10 ng/mL 100 mg
#> STUDY001 Plasma IV DrugA SUBJ001 1 AnalyteA 7 ng/mL 100 mg
#> STUDY001 Plasma IV DrugA SUBJ001 1 AnalyteA 3 ng/mL 100 mg
#> STUDY001 Plasma IV DrugA SUBJ001 1 AnalyteA 1 ng/mL 100 mg
#> AFRLT ARRLT NFRLT ADOSEDUR RRLTU
#> 0 0 0 0.5 hour
#> 1 1 1 0.5 hour
#> 2 2 2 0.5 hour
#> 3 3 3 0.5 hour
#> 4 4 4 0.5 hour
#> 6 6 6 0.5 hour
#> conc_groups TIME std_route IX
#> STUDY001\nPlasma\nIV\nDrugA\nSUBJ001\nAnalyteA 0 intravascular 1
#> STUDY001\nPlasma\nIV\nDrugA\nSUBJ001\nAnalyteA 1 intravascular 2
#> STUDY001\nPlasma\nIV\nDrugA\nSUBJ001\nAnalyteA 2 intravascular 3
#> STUDY001\nPlasma\nIV\nDrugA\nSUBJ001\nAnalyteA 3 intravascular 4
#> STUDY001\nPlasma\nIV\nDrugA\nSUBJ001\nAnalyteA 4 intravascular 5
#> STUDY001\nPlasma\nIV\nDrugA\nSUBJ001\nAnalyteA 6 intravascular 6
#> is.excluded.hl is.included.hl REASON exclude_half.life exclude volume duration
#> FALSE FALSE NA FALSE <NA> NA 0
#> FALSE FALSE NA FALSE <NA> NA 0
#> FALSE FALSE NA FALSE <NA> NA 0
#> FALSE FALSE NA FALSE <NA> NA 0
#> FALSE FALSE NA FALSE <NA> NA 0
#> FALSE FALSE NA FALSE <NA> NA 0
#> Formula for dosing:
#> DOSEA ~ TIME | STUDYID + PCSPEC + DRUG + USUBJID
#> Nominal time column is: NFRLT
#>
#> Data for dosing:
#> STUDYID PCSPEC ROUTE DRUG USUBJID DOSNO ANALYTE AVAL AVALU DOSEA DOSEU
#> STUDY001 Plasma IV DrugA SUBJ001 1 AnalyteA 0 ng/mL 100 mg
#> AFRLT ARRLT NFRLT ADOSEDUR RRLTU
#> 0 0 0 0.5 hour
#> conc_groups TIME std_route IX exclude
#> STUDY001\nPlasma\nIV\nDrugA\nSUBJ001\nAnalyteA 0 intravascular 1 <NA>
#>
#> With 1 rows of interval specifications.
#> With units
#> With imputation: NA
#> No options are set differently than default.