Skip to contents

aNCA (development version)

aNCA 0.2.0

Features added

  • Enhancements to the slides outputs including grouping by PKNCA groups, dose profile, and additional grouping variables (#791)
  • Option to include and apply NCA flag rules with reasons (NCAwXRS) as defined by ADNCA standards. Any record populated within these columns will be excluded for the NCA (#752)
  • Individual and Mean plots tabs now created using the same function, so the layout and plot themes are consistent across both plots (#712)
  • New flagging rule for lambda-z calculations based on r-squared, R2 (#834)
  • New Parameter Selection section in NCA tab allowing to select parameters by study type (#795)
  • The App optionally maps end of sample collection (AEFRLT) for excretion rate parameter calculations: ERTLST, ERTMAX. (#745)
  • Option to upload multiple input files, which will be bound together to form a single ADNCA data set (#821)
  • Section General Exclusions allowing to perform in-App NCA exclusions (#851)
  • Mean plots have been added in the TLGs section, with BLQ handling (#555)
  • CMAX automatically selected in box plots if available (#890)

Bugs fixed

  • ZIP folder with results will now include the exploration tab outputs: individual plots, mean plots (#794)
  • Updated TMAX label from Time of CMAX to Time of CMAX Observation (#787)
  • Bug fix for box/violin plots that were crashing when violin option selected (#786)
  • Summary statistic table changes in grouping variables won’t remove previous summary settings (#840)
  • No longer offering direct PK calculations for renal clearance (RENALCL) parameters. PKNCA is currently inaccurate. Instead, the ratios table should be used (#781)
  • Bug fix for settings upload via zip file output (#832)
  • Bug fix for plotting section where if there is >1 unit the axis label will contain both unique units. (#818)
  • Units table bugs fixed, so it is filtered based on NCA setup and the table is searchable for each column (#870)
  • Bug fix to allow for unrecognized units to be used in AVALU and DOSEU (#861)

aNCA 0.1.0

CRAN release: 2025-12-09

  • Initial CRAN submission.