📢 In the pharmaverse, we are not just adopting new tools, but also fostering a culture of collaboration, innovation and a commitment to continuous learning. We are thus thrilled to update you on the latest developments from our {admiral} family team: {admiralpeds} 0.1 is coming soon on CRAN!

{admiralpeds} is a pediatrics extension package for {admiral}. Its first release is planned by July 2024.

Collaboration

3 companies (Roche, Pfizer, and Cytel), a variety of other community contributors, and David Freedman, a passionate consultant retired from CDC, are working together to create this extension 🤝.

Purpose

The purpose of this new extension is to provide a complementary (to {admiral}) toolbox that enables users to develop specific ADaMs datasets for pediatric clinical trials. Initially the package will focus on anthropometric indicators via child growth/development charts: from WHO and CDC standards.

For guidance and a smooth use of this new extension, ADaM dataset templates, test data, a website and vignettes will all be available at the release time.

New Features

We are starting with 2 new functions to derive Z-scores (SDS) and percentiles:

admiralpeds::derive_params_growth_age()
admiralpeds::derive_params_growth_height()

The first function, derive_params_growth_age() is based on the current age of the patients, while the second one, derive_params_growth_height() depends on the height or body length of the patients. The two functions are flexible enough to choose your own metadata. This could either be company dependent, or the pre-defined ones based on WHO and CDC charts, as created in our ADVS ADaM template. You can also choose the desired parameters (e.g. “BMI”, “HEIGHT”, “WEIGHT”, “HEAD CIRCUMFERENCE”).

Waiting for the release

As for all packages, an entire month will be used for package testing before the release. If you’d like to be involved in this testing phase during June 2024 then please reach out to either of the blog authors via the pharmaverse Slack workspace. More technical details about {admiralpeds} to come at that time, so stay tuned 👀 and subscribe to our newsletter !

What else?

We also are excited to announce that some very early preparations have started on the next package extension joining our family - which will primarily be a collaboration between Roche and Novo Nordisk focused initially on endpoints in clinical trials for obesity. The package name is still to be decided, with the front runner being {admiralmetabolic}. Watch this space for more news!

Last updated

2024-10-16 15:54:29.151194

Details

Source, Session info

Reuse

CC BY 4.0

Citation

BibTeX citation:

@online{gautier2024,
  author = {Gautier, Fanny and Patil, Lina},
  title = {New \{Admiral\} Extension Packages: \{Admiralpeds\} \& More
    Coming Soon!},
  date = {2024-06-17},
  url = {https://pharmaverse.github.io/blog/posts/2024-06-17_new_admiral_ex.../new_admiral_extension_packages_admiralpeds_coming_soon.html},
  langid = {en}
}

For attribution, please cite this work as:

Gautier, Fanny, and Lina Patil. 2024. “New {Admiral} Extension Packages: {Admiralpeds} & More Coming Soon!” June 17, 2024. https://pharmaverse.github.io/blog/posts/2024-06-17_new_admiral_ex.../new_admiral_extension_packages_admiralpeds_coming_soon.html.