Create a PKNCAdata Object for NCA or Slope Analysis — PKNCA_update_data

This function updates a previously prepared PKNCAdata object based on user selections for method, analyte, dose, specimen, and parameters.

Usage

PKNCA_update_data_object(
  adnca_data,
  auc_data,
  method,
  selected_analytes,
  selected_dosno,
  selected_pcspec,
  params,
  should_impute_c0 = TRUE
)

Arguments

adnca_data: A reactive PKNCAdata object
auc_data: A data frame containing partial aucs added by user
method: NCA calculation method selection
selected_analytes: User selected analytes
selected_dosno: User selected dose numbers/profiles
selected_pcspec: User selected specimen
params: A list of parameters for NCA calculation
should_impute_c0: Logical indicating if start values should be imputed

Value

A fully configured PKNCAdata object.

Details

Step 1: Update units in the PKNCAdata object ensuring unique analytes have their unique units

Step 2: Set PKNCAoptions for NCA calculation

Step 3: Format intervals using format_pkncadata_intervals()

Step 4: Apply filtering based on user selections and partial aucs

Step 5: Impute start values if requested

Note*: The function assumes that the adnca_data object has been created using the PKNCA_create_data_object() function.