Create a PKNCAdata Object for NCA or Slope Analysis

This function updates a previously prepared PKNCAdata object based on user selections for method, analyte, dose, specimen, and parameters.

Usage

PKNCA_update_data_object(
  adnca_data,
  method,
  selected_analytes,
  selected_profile,
  selected_pcspec,
  should_impute_c0 = TRUE
)

Arguments

adnca_data

A reactive PKNCAdata object

method

NCA calculation method selection

selected_analytes

User selected analytes

selected_profile

User selected dose numbers/profiles

selected_pcspec

User selected specimen

should_impute_c0

Logical indicating if start values should be imputed

Value

A fully configured PKNCAdata object.

Details

Step 1: Update units in the PKNCAdata object ensuring unique analytes have their unique units

Step 2: Set PKNCAoptions for NCA calculation

Step 3: Format intervals using format_pkncadata_intervals()

Step 4: Apply filtering based on user selections and partial aucs

Step 5: Impute start values if requested

Note*: The function assumes that the adnca_data object has been created using the PKNCA_create_data_object() function.